The Enigma of Dental Health

About the Webinar:-
A two-day webinar series was organized and accomplished on the 23 rd and 24th of October, 2020 by the Ryan Publishers team. It was fortunate to have such dynamic and valuable resource persons convene the webinar session each day. On the 23 rd of October 2020, the webinar talk was delivered by Dr. Shwetha Joshi. She is a qualified dentist, completing her BDS studies from MS Ramaiah Dental College, Bengaluru, and currently, working at Sheffield Teaching Hospitals NHS Trust, in the UK. And on the 24th of October, 2020 the session was convened by Dr. Gurmeet Kaur. She has obtained a Ph.D. in Molecular Microbiology from SASTRA University, Tanjore, and is currently working as a Newton International Postdoctoral fellow at the University of Leeds, in the UK. Both the sessions conducted were informative and had the desired impact on our audience. The presentation slides were quite interesting and engaging. As always at the end of each webinar, relevant questions were raised by our participants, each of which was answered with utmost importance.

Key points discussed:-

Day 1, 23rd October 2020:-

  • What is mouth cancer?
  • Factors that increase the risk
  • Effects of tobacco on oral health
  • The effects of mouth cancer
  • Oral cancer screening saves lives!
  • 8 steps of oral cancer screening
  • Survival rates in detail
  • Incidences of oral cancer
  • 3 signs of oral cancer
  • Common symptoms of oral cancer (7 major symptoms discussed)
  • Biopsy –Nasendoscopy, Panendoscopy
  • Oral Cancer Treatment -Surgery, Radiotherapy, Chemotherapy, Monoclonal Antibody Therapy
  • Conclusion –Wake up-Fight Cancer-Be Kind-Repeat

Day 2, 24th October 2020:-

  • Deciphering the quorum sensing in Streptococcus mutans
  • Deciphering anti-quorum effect of comA inhibitors in Streptococcus mutans – Dental caries and its impact
  • Biofilm formation – the major virulence factor
  • Anti quorum strategy
  • Quorum sensing in S.mutans
  • Com A as target
  • Computer-based de novo design of drug-like molecules(Schrödinger Suite)
  • Top selected Ligands
  • Docking Pose for ComAI
  • MBIC and MBEC
  • Synergistic activity with fluoride
  • Confocal Microscopy
  • Target Specific Mechanism of ComAI
  • MTT Assay (Hep G2 Cells)
  • Acute Oral Toxicity Studies (OECD 425)
  • Efficacy Studies
  • Effect of ComAI on dental caries
  • Teeth Histopathology – CFU of Adherent cells, Liver Histopathology
  • What’s next ?? Inhibitory molecules as Nanoparticles

“Every tooth in a man’s head is more valuable than a diamond.” —Miguel de Cervantes, Don Quixote, 1605

Comments from the participants:-

  • “Nice presentation and thanks for organizing this webinar.”– Arpitha. YP
  • “It is very useful and knowledgeable for us.”– Diptirekha Acharya
  • “It’s very useful and excellent definition.”– E Krithika
  • “Thanks to organizing team for conducting this wonderful two-day webinar”– Ms.N.GEETHA
  • “Good information and nice presentation”– Keerthi A P

  • “More such webinars to be organized”– Sujata Chavan
  • “Thanks to organizing team for conducting these informative sessions“- Ms.N.GEETHA
  • “Very useful and informative session”– Dr.S.JENNY
  • “Excellent, thanks to the organizers”– Mrs. P.S. Geetha Malini
  • Good and effective topic- Mithilesh Kumar Shukla
  • “Thank you for organizing such a good session”– K. Gowri
  • “Excellent Presentation”– Dr Alla Srivani
  • “The webinar was informative”– D PRISCILLA